An Expanded Presence in Health Care

For nearly 30 years, USSC's products have been a major factor in general surgery and have played a supporting role in many other surgical specialties. Now, through internal development and acquisition, the company is launching a multi-
pronged campaign to expand into new markets that offer significant growth potential.

Surgical Stapling
A medical curiosity until 1967, when USSC introduced the world's first practical instrument, surgical stapling reduces operating time and blood loss, minimizes tissue trauma and speeds healing. USSC is the market leader.

Endoscopic Instrumentation
In 1990, USSC's groundbreaking instrumentation for laparoscopic gallbladder removal sparked a revolution in the way surgery is performed. Today, the company continues to lead the market as its products are applied to a widening range of new surgical specialties.

Sutures
Despite new technologies for wound closure, the suture market exceeds
$1.3 billion annually. USSC, which introduced its first line of sutures in 1991, continues to increase its share of suture sales worldwide. Today sutures represent a $100 million business to USSC.

Orthopedic And Neurosurgery
In 1995, USSC purchased Surgical Dynamics, Inc. (SDI). Today SDI is expanding its line of advanced orthopedic and neurosurgical products led by the Ray TFC device for treatment of degenerative disc disease.

Cardiovascular surgery - Mini CABG instrument setCardiovascular Surgery/ Interventional Cardiology
USSC's commitment to become a major player in these multi-billion dollar markets has generated a number of compelling new products, including the first full line of instruments for minimally invasive coronary bypass procedures. Additional products for interventional cardiology and cardio-
vascular surgery are in development.


USSC's ABBI System
Women's Health Care
Women's health care is emerging as one of the most important areas in the health care industry. USSC pioneered laparoscopic procedures in gynecology and recently introduced the ABBI system for minimally invasive breast biopsy. Other new technologies are in development.

New Market Opportunities
USSC has entered into strategic alliances with a number of companies, giving it exclusive worldwide distribution rights to a broad range of exciting new products.

Cancer Detection
A unique technology developed by Neoprobe Corporation may enable surgeons to find previously undetectable cancer. RIGScan® CR49 is currently under regulatory review in the US and Europe for surgical detection of metastatic colorectal cancer. Future applications may include breast, ovarian, lung and prostate cancer.

Surgical Instrumentation
The ULTRA SHEARS device, developed in conjunction with Misonix, Inc., is an innovative cutting instrument that uses high frequency sound waves to coagulate and divide tissue. This instrument can be used in a range of surgical procedures. It provides rapid, precise and safe cutting while reducing costs.

Thermal Ablation System
The EnAbl™ thermal ablation system is a new technology from InnerDyne, Inc. for treating the problem of abnormal uterine bleeding. The system, which uses a heated saline solution, is designed to allow the procedure to take place under local anesthesia in an outpatient setting. The system is currently under clinical evaluation.

Fibrin Glue
A unique fibrin glue product developed by V.I.Technologies (VITEX) greatly reduces the risk of virus transmission. Fibrin glue, used to stop bleeding or seal tissue, is a $350 million market, principally in Europe and Japan. Phase III clinical trials are scheduled to begin in the US in early 1997.

Organ Transplantation
Approximately 100,000 people in the US alone are awaiting donor organs. Unfortunately, many will die before these organs are available. USSC is working with Alexion Pharmaceuticals, Inc., to develop genetically altered pigs whose organs will have two proprietary human genes designed to protect the graft from rejection. The company expects to do the first transplant of these organs into primates within the next 12 months.


Trademarks of United States Surgical Corporation and its subsidiaries throughout this publication are italicized.
Copyright © 1997 United States Surgical Corporation. All Rights Reserved.
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